Figure 3.
Figure 3. Involvement of leukotrienes in collective eosinophil migration. (A) Eosinophil accumulation in response to C. elegans dauers in the presence of MK886 at the indicated concentrations in equal volumes of DMSO (n = 5). (B) Siglec-F staining on bone marrow–derived eosinophils from wild-type and Alox5−/− mice. (C and D) Accumulation of wild-type and Alox5−/− eosinophils in response to C. elegans dauers (n = 9; C) or N. brasiliensis larvae (n = 9; D). (E) Images taken from a fluorescence microscopy time-lapse video (Video 5) of wild-type and Alox5−/− eosinophils migrating toward a C. elegans dauer. The larva is shown at 0 min (left) and after 45 min (right) of culture. Bars, 50 µm. (A–E) Results represent two independent experiments. Error bars indicate standard error of the mean.

Involvement of leukotrienes in collective eosinophil migration. (A) Eosinophil accumulation in response to C. elegans dauers in the presence of MK886 at the indicated concentrations in equal volumes of DMSO (n = 5). (B) Siglec-F staining on bone marrow–derived eosinophils from wild-type and Alox5−/− mice. (C and D) Accumulation of wild-type and Alox5−/− eosinophils in response to C. elegans dauers (n = 9; C) or N. brasiliensis larvae (n = 9; D). (E) Images taken from a fluorescence microscopy time-lapse video (Video 5) of wild-type and Alox5−/− eosinophils migrating toward a C. elegans dauer. The larva is shown at 0 min (left) and after 45 min (right) of culture. Bars, 50 µm. (A–E) Results represent two independent experiments. Error bars indicate standard error of the mean.

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