RU-505 restored spatial retention memory in TgCRND8 mice without affecting motor behavior. (A) The spatial memory of vehicle- or RU-505–treated WT and TgCRND8 mice was assessed using Barnes maze. (B and C) Spatial memory of RU-505–treated WT and TgCRND8 mice was tested using the Barnes maze probe trials. Time to reach the target hole (B), the number of visits to the closed target hole (C), and total distance traveled (D) were assessed (n = 7–11 mice per group). The results corroborate those in Fig. 5 and are from one experiment. All values are means and SEM.