CAA pathology in AD transgenic mice was reduced after long-term treatment with RU-505. (A) Aβ deposits within cortical blood vessels of vehicle- or RU-505–treated Tg6799 mice were visualized using Congo red and laminin (green) labeling (bars, 100 µm). (B) Representative pictures showing parenchymal Aβ deposition in untreated and treated mice (bars, 100 µm). (C and D) CAA and Aβ plaques in (A) and (B) were quantified from 7–10 sections per mouse (n = 5 mice per group; *, P < 0.05). All values are means and SEM. Results are from two independent experiments.