Figure 5.
Differential GPR18-deficient cell distribution in IEL and LPL compartments. (A) CD8αα cell frequency in IELs and LPLs by flow cytometry analysis. Percentages are shown as mean ± SD. (B) Gpr18−/− mixed BM chimeras of the type in Fig. 2 were analyzed for CD8αα T cells in IELs and LPLs. The ratios of Gpr18−/− versus WT were connected for each mouse. (C) Retrovirus-transduced Gpr18−/− BM chimeras of the type in Fig. 3 were analyzed for CD8αα T cells in IELs and LPLs. The ratios of Gpr18-transduced versus untransduced donor-derived cells were connected for each mouse. Data are representative of more than three experiments throughout.