Figure 5.
Figure 5. ATLO conduits connect media SMCs with ATLO compartments and facilitate transport of small molecular weight molecules. (a) Conduits connect the media (M) with HEVs. ECM meshwork (ER-TR7; top left, open arrows) associated with (top left, asterisk) and enfolded by 8.1.1+ fibroblastic reticular cells (top right, filled arrows). Conduit pseudolumen (inset, top right). Conduits at the ATLO periphery (ER-TR7) connect the media with HEVs (bottom panels, arrow; Fig. S4 and Video 2; Fig. S5 and Video 3). (b) ATLO conduits transport low molecular weight molecules. 10 or 500 kD fluorescent dextran was injected i.v.; 15 min later, ATLOs were prepared as described in Materials and methods. Dotted lines indicate ATLO/media border. Note presence of 500 kD dextran in HEV (bottom right) and presence of 10 kD, but not 500 kD, dextran in media. Bars, 50 µm.

ATLO conduits connect media SMCs with ATLO compartments and facilitate transport of small molecular weight molecules. (a) Conduits connect the media (M) with HEVs. ECM meshwork (ER-TR7; top left, open arrows) associated with (top left, asterisk) and enfolded by 8.1.1+ fibroblastic reticular cells (top right, filled arrows). Conduit pseudolumen (inset, top right). Conduits at the ATLO periphery (ER-TR7) connect the media with HEVs (bottom panels, arrow; Fig. S4 and Video 2; Fig. S5 and Video 3). (b) ATLO conduits transport low molecular weight molecules. 10 or 500 kD fluorescent dextran was injected i.v.; 15 min later, ATLOs were prepared as described in Materials and methods. Dotted lines indicate ATLO/media border. Note presence of 500 kD dextran in HEV (bottom right) and presence of 10 kD, but not 500 kD, dextran in media. Bars, 50 µm.

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