Neutrophil influx in skin excision wounds is increased in Adamts13^−/− mice. The number of neutrophils present in skin tissue surrounding the wound 4 h after injury was determined microscopically in H&E-stained sections. (A) Representative images of the wound tissue in Adamts13^−/− and Adamts13^+/+ mice are shown. A deficiency of ADAMTS13 results in an increase in neutrophil extravasation. Bar, 20 μm. (B) Visual count of the number of neutrophils that had emigrated from the blood vessels is shown. (C) Determination of MPO activity in the wounded tissue shows higher activity in Adamts13^−/− mice samples. Data represent the mean ± SEM.