LPS-induced liver injury is diminished by blocking neutrophil adhesion within hepatic sinusoids. The percentage of perfused sinusoids (A) was determined by intravital microscopy, and serum levels of ALT (B) were measured from whole blood as a marker of hepatocellular damage. Untreated WT mice (wt, white bar) and LPS-treated WT mice (wt, black bar) were compared with LPS-treated CD44^−/− mice (CD44−/−), WT mice treated with anti-CD44 mAb and LPS, and WT mice treated with HNase and LPS. Data are presented as the arithmetic mean ± SEM of at least five animals per group. *, P < 0.05 relative to untreated controls; #, P < 0.05 relative to LPS-treated WT animals.