HA is disproportionately expressed in the liver versus other tissues. A modified dual-radio labeling technique was used to determine the expression of HA (A), VCAM-1 (B), P-selectin (C), and E-selectin (D) on the endothelium of various tissues in both untreated mice and mice treated for 4 h with an i.v. injection of LPS. (E) Values for HA expression in the lungs, livers, and hearts of untreated and LPS-treated animals were normalized to published values of vascular surface area for these organs to compare standardized expression levels between organs. All data are expressed as the arithmetic mean ± SEM.