Contact maps showcasing PTx2–VSD residue or POPC lipid interactions averaged over three MD simulation replicas of PTx2–activated VSD IV (now as a part of the full ion channel). PTx2 residues are denoted by the suffix “:T,” while VSD residues are denoted by the suffix “:V.” Error bars are standard errors of the mean from three MD simulation replicas. Only the second half of each MD simulation was used for the analysis.