Contact maps showcasing PTx2–VSD residue or POPC lipid interactions averaged over three MD simulation replicas of PTx2–activated VSD IV system. PTx2 residues are denoted by the suffix “:T,” while VSD residues are denoted by the suffix “:V.” Error bars are standard errors of mean from three MD simulation replicas. Only contact pairs with a duration above 5% (including standard errors) are displayed, and only the second half of each MD simulation was used for the analysis.