Figure 4. Coupled interaction network... | Rockefeller University Press

Figure 4.

Coupled interaction network drives gating conformational change. (a)Δ2G0 between complement pairs of residues at 9′ and 13′ (see Fig. 3 f and Table S4). Left: The anti-clockwise orientation of the arrows shows the strong interactions between 9′ and 13′ complement pairs. Right: Potential local anti-clockwise relative rotation of the residues at 9′ versus 13′. (b) Third-order interaction energies (Δ3G0) between α and non-α residues at 9′, 12′, and 13′ (Table S5). Note the increase in Δ3G0 from 9′ to 13′. (c)Δ3G0 between non-α side chains at 9′, 12′, and 13′. Note the progressive decrease in Δ3G0 from 9′ to 13′ positions. (d) Upper: Low-resolution single-channel current traces from AChRs having L9′T mutations in all the five subunits. Lower: High-resolution currents and dwell-time duration distribution histograms for the above channel.

Coupled interaction network drives gating conformational change. (a) Δ ² G ₀ between complement pairs of residues at 9′ and 13′ (see Fig. 3 f and Table S4). Left: The anti-clockwise orientation of the arrows shows the strong interactions between 9′ and 13′ complement pairs. Right: Potential local anti-clockwise relative rotation of the residues at 9′ versus 13′. (b) Third-order interaction energies (Δ³G₀) between α and non-α residues at 9′, 12′, and 13′ (Table S5). Note the increase in Δ³G₀ from 9′ to 13′. (c)Δ³G₀ between non-α side chains at 9′, 12′, and 13′. Note the progressive decrease in Δ³G₀ from 9′ to 13′ positions. (d) Upper: Low-resolution single-channel current traces from AChRs having L9′T mutations in all the five subunits. Lower: High-resolution currents and dwell-time duration distribution histograms for the above channel.