Figure S3.
![K+o-dependent inhibitions of the KCNQ1 mutants exhibiting fast inactivation of various degrees. (A) Sample current traces of mutant KCNQ1 channels at the five different K+ concentrations indicated. Dashed lines correspond to 0 current. (B)Imax values for channels shown in A normalized to the initial point at 0.2 mM K+o. n = 4–6, error bars indicate ±SEM. (C) The dose–response curves of the channels shown in A after correction of data for theoretical GHK values assuming [K+]in = 109 mM (Weber, 1999). Solid lines represent the fit of the data to the Hill equation, n = 4–6, error bars indicate ±SEM.](https://cdn.rupress.org/rup/content_public/journal/jgp/155/5/10.1085_jgp.202213205/3/jgp_202213205_figs3.png?Expires=1771729946&Signature=HYL0Q5Db1o7j3im3J~AybECPjz~SRkGr0PNYGAi~y6JdTlJ0NMphL-aiB9wzo2PZrDgYj-zglJNVi99kxpwCnUvXCUVGXL3h5Ub5tZetOl0rHPd29r6fiSmTWouUOt4MgYNbPJkSRT1PY1O1FqCdj8sMrpC7LbOmc~6s91jIgf0xJPHAWTAd1~xZiH9ZGF6qCn7Mi1XtA~nPerasFTzttvdv8a58HfDIyHPALZb8osSc1C38F2CTKLXSuVbf-EAlXuygawdoUGmqooLSSEdZ7Dlvyl9g4fi0ZuwnQSKNhcJtY-9lIwgFrbpNIqw7QIq15eeRjsVQQlc1c6NQvu-saQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
K + o -dependent inhibitions of the KCNQ1 mutants exhibiting fast inactivation of various degrees. (A) Sample current traces of mutant KCNQ1 channels at the five different K+ concentrations indicated. Dashed lines correspond to 0 current. (B)Imax values for channels shown in A normalized to the initial point at 0.2 mM K+o. n = 4–6, error bars indicate ±SEM. (C) The dose–response curves of the channels shown in A after correction of data for theoretical GHK values assuming [K+]in = 109 mM (Weber, 1999). Solid lines represent the fit of the data to the Hill equation, n = 4–6, error bars indicate ±SEM.
