Average upper leaflet membrane curvature around ASIC3 TMD in 10% AA and 0% AA membranes. (A) Local membrane curvature averaged over each of the three repeats of 500 ns atomistic simulations in membranes containing 10% AA. Surface is colored by degree of deviation from membrane normal; positive deviation is colored in blue and negative deviation is colored in red. Analysis developed by Lea Thøgersen, as used in Sonntag et al. (2011). (B) Local membrane curvature in three repeats of 500 ns atomistic simulations in POPC-only membranes. (C) Local membrane curvature with embedded ASIC3 average structure (cyan cartoon) in one simulation repeat with a membrane containing 10% AA.