Figure 1.
Model of the hASIC3 and structure of PUFAs. (A) Homology model of hASIC3. One subunit of the trimer is highlighted in color while the rest of the channel is shown in transparent gray cartoon. The ECD is shown in orange cartoon, while the TMD is in blue cartoon, with TM1 in royal blue and TM2 in dark cyan. The dashed lines illustrate the approximate position of the membrane. (B) Surface representation of the open state of hASIC3, colored as in A. Residues R63hASIC3, R65hASIC3, and R68hASIC3 are highlighted in cyan and labeled in one subunit. The dashed triangle indicates the location of lateral fenestrations. (C) Structures of AA (20:4, top) and DHA (22:6, bottom).

Model of the hASIC3 and structure of PUFAs. (A) Homology model of hASIC3. One subunit of the trimer is highlighted in color while the rest of the channel is shown in transparent gray cartoon. The ECD is shown in orange cartoon, while the TMD is in blue cartoon, with TM1 in royal blue and TM2 in dark cyan. The dashed lines illustrate the approximate position of the membrane. (B) Surface representation of the open state of hASIC3, colored as in A. Residues R63hASIC3, R65hASIC3, and R68hASIC3 are highlighted in cyan and labeled in one subunit. The dashed triangle indicates the location of lateral fenestrations. (C) Structures of AA (20:4, top) and DHA (22:6, bottom).

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