Figure 11.
![Pacemaker frequency as a function of IP3concentration. Curves end where the model in question no longer oscillated without changing other parameters. Left: Black, the model of Imtiaz et al. (2007) as reinterpreted by Hancock et al. (2022). Green, the model of Hancock et al. (2022). Blue, the new model. Right: The new model under control (blue), Ano1-KO (red), and IP3R-KO (grey) conditions. In depicting the range of [IP3] values over which oscillation occurred, the plots are analogous to bifurcation diagrams.](https://cdn.rupress.org/rup/content_public/journal/jgp/155/12/10.1085_jgp.202313355/11/jgp_202313355_fig11.png?Expires=1771588202&Signature=bb1jja08ocZRfChYL0rHECF9~NfteYHxqf5XNHrYCnJBZ7pfneUnuJ1ucGrDyyu8-eUtHQmr~3aSyW6oVFU4kHpY6gSq3s3TJ67bGZL9PEbe~PPnZ~0guCVH8dl79uMMKFnqF-gXK1h0lRbOxE5m72wT1E-qBx04ti~yv-LM8vYBznlAOGvWgp9ZPFXwQnUfBvukudbTnR~DeLWXlt028K6s3H7xI0hbgz2ZATK3aQflc0dJNxNpqZcWIJderoJWolRsvZFcuqQ-Ck6Bu8YkVJD5qZYBIlHBnKvqvM~JHftaIf3GdU49FA23xMKg9MQ~XQBLkL~5reQ5sOtUkGFBLw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Pacemaker frequency as a function of IP 3 concentration. Curves end where the model in question no longer oscillated without changing other parameters. Left: Black, the model of Imtiaz et al. (2007) as reinterpreted by Hancock et al. (2022). Green, the model of Hancock et al. (2022). Blue, the new model. Right: The new model under control (blue), Ano1-KO (red), and IP3R-KO (grey) conditions. In depicting the range of [IP3] values over which oscillation occurred, the plots are analogous to bifurcation diagrams.
