Figure 10.
![Waveforms of simulated cytosolic [Ca2+] (µM), membrane potential (mV), L-type channel Ca2+current (pA), and Ano1 channel Cl−current (pA), under control conditions, Ano1-KO, IP3R-KO, and combined Ano1/IP3R knock-out. See caption to Fig. 5 regarding polarity of Ano1 current, which is non-zero throughout diastole under IP3R-KO (see Coupled clocks and IP3R-KO data).](https://cdn.rupress.org/rup/content_public/journal/jgp/155/12/10.1085_jgp.202313355/11/jgp_202313355_fig10.png?Expires=1771588192&Signature=ZfUJgCYLK1SLB0BgOCOwWgpbD7J2x9S~YBQoGWevMYLAEEqRhSfAVvwC2RMvxn-siuWeV0CM~bQ4rJA64FHwQq6QWAsNjafw3SMrft5BgOUHA42BXijEbSZPSrGS6BplNUr76Cd3APg10gyQC1-Q2-roPS0GdKMSqMuW4oeTPbVW9Nd2cug4ZOgVVjZwK3xNnZMTuJDgyssPyX9BR3tiXEmAceBD9Sx3fxXCJEgLlUWRsdTUpKLwIqKqN1iWTSDYSk~cX534e6KUOhe48vAmGxfrQzE8pVy075aGW0uv72sEz7BBQF5rhqINAASnCqfaB~PEF9b4irQshUxoevUqlw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Waveforms of simulated cytosolic [Ca 2+ ] (µM), membrane potential (mV), L-type channel Ca 2+ current (pA), and Ano1 channel Cl − current (pA), under control conditions, Ano1-KO, IP 3 R-KO, and combined Ano1/IP 3 R knock-out. See caption to Fig. 5 regarding polarity of Ano1 current, which is non-zero throughout diastole under IP3R-KO (see Coupled clocks and IP3R-KO data).
