Figure 6.

Superimposed traces from three runs with c = 0 (no effect of I L on Z), showing waveforms after start-up transients have decayed, under control conditions (blue), Ano1-KO (red), and IP 3 R-KO (grey). Top: Cytosolic calcium concentration. Bottom: Membrane potential. The AP frequencies are 8.0 (control), 4.9 (Ano1-KO), and 6.9 (IP3R-KO)/min. Parameter values that differ from those in Table 1: P = 0.9 µM, Jxce = 0.056vc/bc, Kce = 0.1275 µM, A1 = 0.003vc/bc µmol/s, A2 = 0.02/bc/s, Kc = 0.3 µM, Vkh = 0.4 mV.

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