Figure 3.
![The existing model cannot emulate the effects of IP3R knock-out. Time traces from the existing model by Hancock et al. (2022) with traces for IP3R-KO added. Ano1-KO = knock-out of anoctamin-1 Cl− channels. Note the large change in IP3R-KO waveform size and frequency between early and late simulated time, owing to a gradual increase of store [Ca2+] to an asymptotic value. Adapted from Fig. 7 a of Hancock et al. (2022), with permission from Computers in Biology and Medicine.](https://cdn.rupress.org/rup/content_public/journal/jgp/155/12/10.1085_jgp.202313355/11/jgp_202313355_fig3.png?Expires=1773661982&Signature=xRbVGmlYs7DMkwxMAUfaEv6Fa78dDVcNnv8rnQgpQAdE9dBupa3cKJIFRYgSLytRPQuXZjNuYKect6biSo~6~FFgZDm0P-gClnLCQR7T9wtB1c3saJ3N5ipqMPZLFtBqPcriBq~-xRceNS~Mvsqw6XNe7-Pbk0NDmYNMfAEKFM6hGKXv~xQNxjWBFcytEm-qkgz5gf3ZpHWbUGGN3hG7twugkA9iu0Up6hJD3VeGlc3eeMoqrAJRls5V032Jn0DTX19JHLBrB-N-6xC2NdDdt4z1uyHUkIN83qRmk47kK9q66MZcfLdfp~COTYQ2E6mJ4OMjFx5ZiQ~9C6AwUVqJJg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The existing model cannot emulate the effects of IP 3 R knock-out. Time traces from the existing model by Hancock et al. (2022) with traces for IP3R-KO added. Ano1-KO = knock-out of anoctamin-1 Cl− channels. Note the large change in IP3R-KO waveform size and frequency between early and late simulated time, owing to a gradual increase of store [Ca2+] to an asymptotic value. Adapted from Fig. 7 a of Hancock et al. (2022), with permission from Computers in Biology and Medicine.
