Figure 1.
IP
3
R knock-out changes the AP. Membrane potential versus time, recorded from murine LMCs ex vivo. Here, the frequency of APs averages 17.8/min under control conditions (black trace) and 8.2/min under IP3R-KO (red trace). Abbreviations: IP3R1 = IP3 receptor 1, fl/fl = alleles floxed but knock-out not activated, KO = knock-out activated.