Figure 4.
PIP2potentiates the clockwise twisting motions. (a) The difference of the mean (±SEM) diagonal Cα distance (ΔΔDist_j) between the simulations with PIP2 and without PIP2. The residues forming the HBC gate and the G-loop region are designated by orange and green shade, respectively. The slide helix and TM1 region is shaded in pink. (b and c) Kir2.2 ribbon diagram color coded by the differential mean diagonal distance deviation (ΔΔDist_j) shown in a. The color range is shown in the bar. Both side (b) and top-down (c) views show the two opposing subunits. Curved gray arrows indicate a motion that satisfies the major pattern of diagonal distance changes in the CTD by PIP2 binding. Refer to the image caption for details.

PIP 2 potentiates the clockwise twisting motions. (a) The difference of the mean (±SEM) diagonal Cα distance (ΔΔDist_j) between the simulations with PIP2 and without PIP2. The residues forming the HBC gate and the G-loop region are designated by orange and green shade, respectively. The slide helix and TM1 region is shaded in pink. (b and c) Kir2.2 ribbon diagram color coded by the differential mean diagonal distance deviation (ΔΔDist_j) shown in a. The color range is shown in the bar. Both side (b) and top-down (c) views show the two opposing subunits. Curved gray arrows indicate a motion that satisfies the major pattern of diagonal distance changes in the CTD by PIP2 binding.

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