Figure 2. PIP 2 interaction with... | Rockefeller University Press

Figure 2.

PIP2interaction with open-conductive Kir2 channels. (a) Salt bridges formed between PIP2 and the basic residues forming the binding pocket observed in the crystal structure (left) or in a representative conformation obtained by MD simulations (right). The distances are in Å. (b) A violin plot showing the distance changes of each salt bridge during MD simulations. (c) A representative conformation obtained by MD simulations providing the structural basis of drastic close apposition of K220 to PIP2. Statistical analysis was done by a one sample t and Wilcoxon test using Prizm 10 (GraphPad Software). Refer to the image caption for details.

PIP ₂ interaction with open-conductive Kir2 channels. (a) Salt bridges formed between PIP₂ and the basic residues forming the binding pocket observed in the crystal structure (left) or in a representative conformation obtained by MD simulations (right). The distances are in Å. (b) A violin plot showing the distance changes of each salt bridge during MD simulations. (c) A representative conformation obtained by MD simulations providing the structural basis of drastic close apposition of K220 to PIP₂. Statistical analysis was done by a one sample t and Wilcoxon test using Prizm 10 (GraphPad Software).