Figure S3.

α-Helical contents of four TM2 helices of 15 MD trajectories simulated without PIP 2 . Ribbon diagrams of two opposing TM2 helices showing the exemplary deformation of α-helical conformation in the simulations without PIP2. Arrowheads indicate the parts that are deformed from canonical α-helical conformation. The four simulations used for the PIP2-dependent conformational changes are marked in red.

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