Figure 6.
A 24-state model of AdiC’s conformational kinetics. All states are denoted as described in Results. The middle portion illustrates the transitions of apo AdiC among eight identified states differing in conformation or energy. The left and right portions illustrate the transitions of AdiC bound with two types of ligand, one side for each type. Transition rate constants ki,j and kj,i, associated with arrows, indicate the reversible transitions between corresponding states i and j (Tables S1, S2, S3, and S4). The transitions directly involving the binding and unbinding of a ligand are labeled with a .
