Figure S5.
Impact of the CTD charge density on SPM unbinding. Fraction of simulations relieved from SPM pore block at different voltages observed in simulations of the WT (Sims. 61–81, 83–90) and in the E225A/E300A and E225A/R261Q CTD double mutants (Sims. 93–120 and Sims. 121–148, respectively). SPM unbinding times were identified when the distance from SPM to the D173 center of mass (Cα atoms) exceeded 20 Å (30 ns-running medians).

Impact of the CTD charge density on SPM unbinding. Fraction of simulations relieved from SPM pore block at different voltages observed in simulations of the WT (Sims. 61–81, 83–90) and in the E225A/E300A and E225A/R261Q CTD double mutants (Sims. 93–120 and Sims. 121–148, respectively). SPM unbinding times were identified when the distance from SPM to the D173 center of mass (Cα atoms) exceeded 20 Å (30 ns-running medians).

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