Results of numerical simulations illustrating importance of Ca v 1.3 isoform of LCC for AP firing and the effects of randomness in CRU positions. (A) The two plots show results of our sensitivity analysis with various contribution of Cav1.3 into ICaL performed for two different CRU distributions: uniformly random and square lattice. Multicolor arrows show the total effects of randomness (black and green) and Cav1.3 (blue and orange). Data points are average CLs evaluated between 5 and 16.5 s after simulation onset. (B and C) Effect of βAR stimulation in the models with 50% of Cav1.2 in ICaL. Intervalograms illustrate a much stronger stimulation effect in the cell model with square lattice distribution of CRUs versus uniformly random distribution of CRUs.
