![Sizes of LCRs increase during diastolic depolarization via
propagating CICR as disorder in CRU positions increases from square
lattice to uniformly random (from top to bottom). Shown are
instant distributions of local
[Ca]sub ([Ca] under
cell membrane) at the same membrane potential of −45 mV, i.e.,
close to the ICaL activation threshold. [Ca]sub is coded by a color scheme
shown at the bottom from 0.15 to 10 μM; open CRUs are shown by
white dots. Closed CRUs in refractory period are shown by blue dots;
closed reactivated CRUs (available to fire) are shown by green dots. JSR
Ca level is coded by respective shade (white, blue, or green) with a
saturation level set at 0.3 mM. See respective Videos 1, 2, 3, 4, and 5.](https://cdn.rupress.org/rup/content_public/journal/jgp/154/9/10.1085_jgp.202113061/4/jgp_202113061_fig6.png?Expires=1771766442&Signature=eDj~Ir~QhDaT1CshT~aND9myhfD6AIRHxPtT~usgBOAosyaG689MSfre67MDLPR3tWjqlPhFFhmfuxBhd~SfeA-n3Yf1uv4VQC9FVDpnGRyudfdv8jwJ76Utm~XTsl3bse3MC5c6lU1vwkV0DhBFzkgveSeIGMw4rW6dBmAdEt7dBUlx7UTX7Sjurg02j4tCX~SClJgyjZPRk7-JAS9Fnqv1cK6kUBkhwzeMYu-Z~DeX5iizqVVVLBbzNwwxfnVenYXJ1kJS~ssRNj0LOSZT4Fn-5l0szhmDdoV536DyAoDPE2bomGowrCdyTFjrzcSYQON6iuYujDXGlL6yof1eQw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Sizes of LCRs increase during diastolic depolarization via propagating CICR as disorder in CRU positions increases from square lattice to uniformly random (from top to bottom). Shown are instant distributions of local [Ca]sub ([Ca] under cell membrane) at the same membrane potential of −45 mV, i.e., close to the ICaL activation threshold. [Ca]sub is coded by a color scheme shown at the bottom from 0.15 to 10 μM; open CRUs are shown by white dots. Closed CRUs in refractory period are shown by blue dots; closed reactivated CRUs (available to fire) are shown by green dots. JSR Ca level is coded by respective shade (white, blue, or green) with a saturation level set at 0.3 mM. See respective Videos 1, 2, 3, 4, and 5.
