Normalized calcium transients from different experimental and computational studies. We plotted the temporal dynamics of the small idealized thin spine (0.035 µm3) and large idealized mushroom spine (0.643 µm3) versus reported experimental calcium transients from previous studies (Sabatini et al.,2002; Hoogland and Saggau, 2004; Segal and Korkotian, 2014) and computational model results from previous studies (Bell et al., 2019; Bartol et al., 2015; Rubin et al., 2005; Hu et al., 2018). The various experimental transients are reported in terms of fluorescence, and we assumed the transients were linearly proportional to concentration (Yasuda et al., 2004). We normalized the various transients and time shifted them for a more direct comparison. We plotted from Fig. 1 f in Sabatini et al. (2002), Fig. 1 in Segal and Korkotian (2014), and Fig. 2 d in Hoogland and Saggau (2004). We also compared Fig. 3 of Bell et al. (2019), Fig. 5 of Hu et al. (2018), Fig. 1 a of Rubin et al. (2005), and Fig. 7 i of Bartol et al. (2015).
