Morphology of R2509C RYR1 homozygous embryos. Three R2509C-Hom fetuses (E19−E20) were obtained from different heterozygous mothers. The fetuses showed abnormal death accompanied by subcutaneous hemorrhage (yellow arrows; mice 1–3), subcutaneous effusion (white arrows; mice 1 and 2), and translucent skeletal muscles (black line circle; mouse 3).