Figure 4.
AQP4 deletion does not alter the distribution of fluorescent dextrans in brain following high-volume cisternal injection.(A) Left: Low-magnification images showing distribution of 70-kD dextran. Right: High-magnification images showing distribution of 2,000-, 70-, and 10-kD fluorescent dextrans in brain cortex after high-volume injection in wild-type (AQP4+/+) and AQP4 knockout (AQP4−/−) mice. (B) Top: Fraction of brain surface labeled with dextrans (eight mice per genotype; n.s., not significant, P = 0.9616, t test). Bottom: Fraction of brain covered with perivascular label after thresholding (eight mice per genotype, n.s., not significant, P = 0.6969, t test). (C) Distance of dye penetration in parenchyma and perivascular spaces in animals fixed 30 min after cisternal injection (differences between genotypes are not significant at P > 0.999, repeated-measures two-way ANOVA with Bonferroni posttest; n = 8 mice each).

AQP4 deletion does not alter the distribution of fluorescent dextrans in brain following high-volume cisternal injection. (A) Left: Low-magnification images showing distribution of 70-kD dextran. Right: High-magnification images showing distribution of 2,000-, 70-, and 10-kD fluorescent dextrans in brain cortex after high-volume injection in wild-type (AQP4+/+) and AQP4 knockout (AQP4−/−) mice. (B) Top: Fraction of brain surface labeled with dextrans (eight mice per genotype; n.s., not significant, P = 0.9616, t test). Bottom: Fraction of brain covered with perivascular label after thresholding (eight mice per genotype, n.s., not significant, P = 0.6969, t test). (C) Distance of dye penetration in parenchyma and perivascular spaces in animals fixed 30 min after cisternal injection (differences between genotypes are not significant at P > 0.999, repeated-measures two-way ANOVA with Bonferroni posttest; n = 8 mice each).

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