Q277G rapidly recovers from desensitization over a wide pH range. (A) Outside-out patch recordings of cASIC1 Q277G recovery from desensitization with interpulse pH values of 8.0, 7.4, and 7.0 (upper, middle, and lower traces, respectively). All data from the same patch. Note the break and change in time base between conditioning and test pulses. (B and C) Summary recovery curves (B) and time constants (C) for Q277G recovery at different interpulse pH values. All pH values tested in the same patch. Symbols denote individual patches, and error bars show SEM. Dotted line is the recovery time course of WT cASIC1 with pH 8.0 drawn from Rook et al., 2020a.