Comparison between some of the relevant physicochemical properties of the compounds used in this study. (a) Chemical structures of the compounds used in this study. (b) 3-D structures of the compounds. (c) Volume (ų) and area (Ų) for each compound were calculated using University of California, San Francisco Chimera. LogP values are obtained from the ChEMBL database. CBD, lidocaine, and flecainide all interact with the LA site inside the Nav pore. TTX interacts with the outer selectivity filter of the Nav pore. CBD is several times more hydrophobic than the other compounds. CBD is larger than lidocaine and slightly smaller than flecainide.