$N O p e a k$ distribution of two CRSs differing in RYR vicinity . The histograms were constructed from 10,000 simulated CREs per compared CRS, shown as red and blue columns. Both CRSs were of the narrow type, pattern B, 20 RYRs, and i_Ca = 0.25 pA. (Insets) The two CRSs were selected from the set of 100 CRSs generated for the same determinants; red RYRs had the lowest and blue RYRs had the highest RYR vicinity (v) in the CRS set.