Figure 3. Types and characteristics of... | Rockefeller University Press

Figure 3.

$Types and characteristics of CREs. The exemplified data set consisted of 10,000 CREs, generated in a narrow CRS of pattern B, 20 RYRs, and iCa of 0.25 pA. The color-coded histogram bins correspond to traces of the same color. (A) Examples of three types of CREs: a quark (left), a blip (center), and a spark (right), shown as simulated time courses of NO (upper panels) and as their calculated x-t fluorescence signals (lower panels). Arrowheads indicate positions of NOpeak and TTP. The color map indicates the relative amplitude of fluorescence signals, common for all three images. (B) The distribution of NOpeak values in the data set. Quarks, blips, and sparks represented 44%, 32%, and 24% of traces, respectively. The nadir of the histogram was at six simultaneously open RYRs (arrow). (C) The distribution of TTP values in the data set. The thin black columns correspond to the fraction of blips. The red, blue, and green columns in B and C correspond to the three respective events depicted in A. Note the logarithmic scales on the ordinates.$

Types and characteristics of CREs. The exemplified data set consisted of 10,000 CREs, generated in a narrow CRS of pattern B, 20 RYRs, and i_Ca of 0.25 pA. The color-coded histogram bins correspond to traces of the same color. (A) Examples of three types of CREs: a quark (left), a blip (center), and a spark (right), shown as simulated time courses of N_O (upper panels) and as their calculated x-t fluorescence signals (lower panels). Arrowheads indicate positions of $N_{O}^{p e a k}$ and TTP. The color map indicates the relative amplitude of fluorescence signals, common for all three images. (B) The distribution of $N_{O}^{p e a k}$ values in the data set. Quarks, blips, and sparks represented 44%, 32%, and 24% of traces, respectively. The nadir of the histogram was at six simultaneously open RYRs (arrow). (C) The distribution of TTP values in the data set. The thin black columns correspond to the fraction of blips. The red, blue, and green columns in B and C correspond to the three respective events depicted in A. Note the logarithmic scales on the ordinates.