Figure 1.
The tarantula skeletal muscle myosin IHM. Related to PDB accession no.3JBH. (A) IHM with the BH and the FH shown in green and blue, respectively, and S2 shown in gray. (B) Superimposed motor domains of the IHM PDB 3JBH FH and BH as compared with the crystal structure of scallop myosin PDB accession no. 1QVI (in tan) representing the “prepower stroke” bent conformation (2.6 Å resolution; Argopecten irradians; Gourinath et al., 2003) with the BH and FH lever arms angled to allow the formation of the IHM (see Fig. 7). (C) Tarantula skeletal muscle lattice model showing a segment of relaxed tarantula skeletal muscle thick filament formed by two sets of BH (green) and FH (blue) helices above the myosin tails (gray), surrounded by 12 thin filaments (a). In the upper images, only the lateral thin filaments are shown. In b, the helices of FHs are removed, and in c, both sets of BHs and FHs are removed, leaving only the S2s and tails. Scale bars, 14.5 nm.

The tarantula skeletal muscle myosin IHM . Related to PDB accession no.3JBH. (A) IHM with the BH and the FH shown in green and blue, respectively, and S2 shown in gray. (B) Superimposed motor domains of the IHM PDB 3JBH FH and BH as compared with the crystal structure of scallop myosin PDB accession no. 1QVI (in tan) representing the “prepower stroke” bent conformation (2.6 Å resolution; Argopecten irradians; Gourinath et al., 2003) with the BH and FH lever arms angled to allow the formation of the IHM (see Fig. 7). (C) Tarantula skeletal muscle lattice model showing a segment of relaxed tarantula skeletal muscle thick filament formed by two sets of BH (green) and FH (blue) helices above the myosin tails (gray), surrounded by 12 thin filaments (a). In the upper images, only the lateral thin filaments are shown. In b, the helices of FHs are removed, and in c, both sets of BHs and FHs are removed, leaving only the S2s and tails. Scale bars, 14.5 nm.

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