Figure 5.
The conformational shift of Pgp. Left: The mouse Pgp structure in the inward-facing conformation (Li et al., 2014). Highlighted are two residues, 511 and 1043, which are on opposite halves of Pgp. Middle: The structure of human Pgp in the outward-facing conformation (Kim and Chen, 2018). Right: The closure of the NBDs is shown in detail, highlighting the nearness of the residues 511 and 1043 in the outward-facing conformation. PDB, Protein Data Bank.

The conformational shift of Pgp. Left: The mouse Pgp structure in the inward-facing conformation (Li et al., 2014). Highlighted are two residues, 511 and 1043, which are on opposite halves of Pgp. Middle: The structure of human Pgp in the outward-facing conformation (Kim and Chen, 2018). Right: The closure of the NBDs is shown in detail, highlighting the nearness of the residues 511 and 1043 in the outward-facing conformation. PDB, Protein Data Bank.

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