Figure 7.
![Graphs of RMSF showing regional changes in stability. RMSF from MD simulations of the C-lobe of apo-CaMWT is shown in blue (first simulation [sim]) and purple (second simulation), while RMSF from MD simulations of the C-lobe of apo-CaMF90L, apo-CaMF93L, and apo-CaMF142L mutants are shown in red, orange, and green, respectively. Diagrams above the graphs depict helices 1–4 from the C-lobe together with amino acid residues and are scaled to match the residue numbering of the graph. Locations of the three mutations are indicated by their respective colored dot on the graph and bars above the helices. Ca2+-binding sites are indicated with purple dots together with the numbers for the amino acid residues. Data shown are mean ± SD.](https://cdn.rupress.org/rup/content_public/journal/jgp/152/12/10.1085_jgp.202012667/3/jgp_202012667_fig7.png?Expires=1771645394&Signature=EKaiH23krlWeQglAuYrFFDI0hHRnie66XbYd2xAvsioR7KU~lq~mAjhWkNsBueHgEsvDAb9sEXy83tzNrxF~uKclKhutNTaa67bGamcAmjuJGzvoJq14DleksYYwVNjh50uFyziIFg9tYHgOhzAuagyCykSvbmDF~3GGW3Dmqx~s3Wmv1qedtYMVlyM6GFXlUKU-VAYmFo6rr9yv1Nzhw2qiAHpyxQgheF67uW~bJAZFpiN~l6AXMg~zZ3uy8YuMMQ3d0IOy40NhsrXdq~~o354PUVn8HJ4NYMkOoqHxKGC~ZzTzyX~p74amTu~lIESsWt~eq-ABYDAUdUrv3UGKdA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Graphs of RMSF showing regional changes in stability. RMSF from MD simulations of the C-lobe of apo-CaMWT is shown in blue (first simulation [sim]) and purple (second simulation), while RMSF from MD simulations of the C-lobe of apo-CaMF90L, apo-CaMF93L, and apo-CaMF142L mutants are shown in red, orange, and green, respectively. Diagrams above the graphs depict helices 1–4 from the C-lobe together with amino acid residues and are scaled to match the residue numbering of the graph. Locations of the three mutations are indicated by their respective colored dot on the graph and bars above the helices. Ca2+-binding sites are indicated with purple dots together with the numbers for the amino acid residues. Data shown are mean ± SD.
