K4750Q mutation-driven kinetic alterations in cytosolic Ca²⁺ activated channels. (A) Dwell time distributions (pCa_cyt 5) from WT and K4750Q. (B) State models of WT and K4750Q. (left) WT: maximum likelihood value (LL) = 16,270, events = 3,928; (right) K4750Q: LL = 7,343, events = 1,734. (C) Model-based simulated traces from WT and K4750Q. n = 6 for WT and mutant channels.