Figure 3. Pressure dependence of solute... | Rockefeller University Press

Figure 3.

$Figure 3. Pressure dependence of solute movement in brain ECS. (A) Influence of details of Voronoi cell geometry on model predictions. Four cell geometries were modeled: Voronoi 1 and 2, generated using different initial sets of random numbers with the same ECS width; Voronoi 3, with 25% reduced ECS width; and Voronoi 4, with 25% increased ECS width (each for the same ECS volume fraction). Images of CB/CBo shown in the triangular computational domain at t = 60 and 600 s (left) and the kinetics of spatially integrated CB in the ECS (ΣCB; right). (B) Influence of ECS volume fraction, α. Computations as in A for ΔP = 1 mmHg, for the indicated α. (left) Pseudocolored images as in A. (right) Kinetics of tracer solute accumulation in ECS for the indicated α.$

Pressure dependence of solute movement in brain ECS. (A) Influence of details of Voronoi cell geometry on model predictions. Four cell geometries were modeled: Voronoi 1 and 2, generated using different initial sets of random numbers with the same ECS width; Voronoi 3, with 25% reduced ECS width; and Voronoi 4, with 25% increased ECS width (each for the same ECS volume fraction). Images of C_B/C_B^o shown in the triangular computational domain at t = 60 and 600 s (left) and the kinetics of spatially integrated C_B in the ECS (ΣC_B; right). (B) Influence of ECS volume fraction, α. Computations as in A for ΔP = 1 mmHg, for the indicated α. (left) Pseudocolored images as in A. (right) Kinetics of tracer solute accumulation in ECS for the indicated α.