Figure 2.
Figure 2. Apo- and PIP2-bound K62W crystal structures. (A) K62W mutant channel structures determined without (Apo-, orange; PDB no. 5KUK) or with PIP2 (PIP2-bound, red; PDB no. 5KUM) are shown in ribbon diagram (PIP2 shown as space-filling balls). (B) Ribbon diagrams, colored to indicate the conformational displacement perpendicular to the membrane plane (along the z axis) between the two structures. The distance changes along the z axis at every Cα were computed after alignment of the two crystal structures at selectivity filter backbone atoms (residue 143–148). (C) I177 and M181 residues in the bundle crossing region are shown as space-filling spheres, for Apo (left) and PIP2 bound (right).

Apo- and PIP2-bound K62W crystal structures. (A) K62W mutant channel structures determined without (Apo-, orange; PDB no. 5KUK) or with PIP2 (PIP2-bound, red; PDB no. 5KUM) are shown in ribbon diagram (PIP2 shown as space-filling balls). (B) Ribbon diagrams, colored to indicate the conformational displacement perpendicular to the membrane plane (along the z axis) between the two structures. The distance changes along the z axis at every Cα were computed after alignment of the two crystal structures at selectivity filter backbone atoms (residue 143–148). (C) I177 and M181 residues in the bundle crossing region are shown as space-filling spheres, for Apo (left) and PIP2 bound (right).

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