GJ channels contain fast and slow gating mechanisms. (A) Schematic of the GJ channel illustrating fast gates (orange) that close the channel partially to the so-called residual state and the slow gates (blue) that close the channel fully. (B) Schematic of the GJ channel is combined with the principal electrical scheme composed of four variable resistances in series attributed to the fast (γ_F) and slow (γ_S) gates. (C) A schematic of possible transitions of the gate, which has open (o) and closed (c) states.