Structural architecture of TRPV1. (A) The side view showing ARD (red), MPD (green), helices S1–S4 (cyan), helices S5–S6 (purple), and CTD (blue) for a representative subunit, with the remaining subunits colored in light gray, and residues G643 and I679 (at the selectivity filter and lower gate) shown as spheres (colored in orange and yellow, respectively). (B) The top view with the same color scheme as A. (C) Dynamic domain partition for mode 6, where domains T1–T4 are colored purple, silver, pink, and tan; domains I1 and I2 are colored cyan and blue; domains A1–A4 are colored green, red, yellow, and orange; the arrows represent the rotational axes for interdomain movements using the following color scheme: the axis of rotation of domain X relative to domain I2 is represented by an arrow with the tip colored the same as domain X; residues G643 and I679 are shown as spheres. (D) Dynamic domain partition for mode 13 with the same color scheme as C.