Figure 1.
Figure 1. Sequence alignment of P-loops in NavAb and Nav1.4 and sequences of μ-conotoxins GIIIA, PIIIA, and KIIIA. In the P-loops the selectivity filter residues and outer carboxylates are shown in bold. The polar residues, which stabilize relative folding of P1 and P2 helices in the NavAb structure (underlined), are in matching positions in Nav1.4. In the toxins, critical basic residues in matching positions are shown in bold.

Sequence alignment of P-loops in NavAb and Nav1.4 and sequences of μ-conotoxins GIIIA, PIIIA, and KIIIA. In the P-loops the selectivity filter residues and outer carboxylates are shown in bold. The polar residues, which stabilize relative folding of P1 and P2 helices in the NavAb structure (underlined), are in matching positions in Nav1.4. In the toxins, critical basic residues in matching positions are shown in bold.

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