cpPME in health and neuroinflammatory disease. Schematic illustrations depict how the cpPME, including cpLVs and olfactory nerve bundles, intersect with CSF drainage and immune interactions under pathological states. In the healthy (center) condition, CSF exits near olfactory nerve bundles and drains via cpLVs. In AD (top left), Aβ accumulates, potentially due to impaired CSF outflow and cpLV dysfunction, with possible effects on olfactory signaling. In MS (bottom left), fibrinogen deposition, lymphatic expansion, and myelin antigen drainage promote local antigen presentation by cpLVs and DCs, contributing to tolerogenic or inflammatory interactions. In stroke (bottom center), ischemic events drive lymphatic expansion and waste clearance, while hemorrhagic strokes facilitate red blood cell drainage. In brain cancer (top right), tumor-associated antigens may accumulate due to blocked CSF efflux, with possible perineural spread. In CNS infection (bottom right), pathogens can accumulate at CP, with cpLVs mediating pathogen-specific antigen drainage and edema resolution, and resulting in possible lymphatic expansion or dysfunction. Together, these models highlight the cpLV niche as a dynamic regulator of immune drainage across diverse neurological diseases.