Schematic depicting the current model of p62-dependent exosome secretion. Upon ATG7-dependent conjugation of LC3-II to late endosomes, p62 localizes to late endosomes and recruits cytoplasmic RBPs that are bound to selected miRNAs (such as La bound to miR-122 via LaM and RRM1). The RNP complexes are then sequestered into ILVs and secreted within exosomes upon fusion of MVBs with the plasma membrane.