p62 mediates the secretion of miR-122 and other exosomal miRNAs. (A) Volcano plot showing miRNAs present in immunoisolated sgNT exosomes compared with sgSQSTM1 exosomes (n = 3). (B) Volcano plot showing miRNAs present in HA-CD63-mEGFP^ECL1 sgNT cells compared with sgSQSTM1 cells (n = 3). (C) Changes in the intracellular and exosomal levels of miRNAs of interest from HA-CD63-mEGFP^ECL1 sgNT and sgSQSTM1 cells and immunopurified exosomes (n = 3). Mapped miRNA reads were normalized to the total number of miRNA reads in each sample.