Distribution of nearest-neighbor distances in our model is close to that measured experimentally. (A) An example of the network of large (7 × 7 RyRs) and small (3 × 3) couplons used in the model. (B) The same network of RyRs as in A but as it would be seen using a confocal microscope with diffraction-limited resolution of ∼200 nm. (C) Distribution of nearest-neighbor distances of the simulated image in B. (D and E) An example of experimentally measured RyR-labeled fluorescence (cell 10 bottom in Supplement 2), with the distribution being close to our simulated RyR distribution shown in C.