Figure 2.
Figure 2. Low concentrations of nicotine (0.4 mg/kg/h) up-regulate α6-GFP* nAChRs in midbrain neurons. (A and B) Direct fluorescence imaging of VTA and SNc neurons in mice expressing α6-GFP subunits after treatment with saline or nicotine (0.4 mg/kg/h, 10 d). Bars, 100 µm. (C1 and C2) Quantification of α6-GFP intensities of neurons in saline- or nicotine-treated mice (n = 4 mice). (D1 and D2) Cumulative percentage plots show changes in α6-GFP fluorescence in the SNc and VTA with chronic nicotine (0.4 mg/kg/h; n = 4 mice). *, P < 0.05.

Low concentrations of nicotine (0.4 mg/kg/h) up-regulate α6-GFP* nAChRs in midbrain neurons. (A and B) Direct fluorescence imaging of VTA and SNc neurons in mice expressing α6-GFP subunits after treatment with saline or nicotine (0.4 mg/kg/h, 10 d). Bars, 100 µm. (C1 and C2) Quantification of α6-GFP intensities of neurons in saline- or nicotine-treated mice (n = 4 mice). (D1 and D2) Cumulative percentage plots show changes in α6-GFP fluorescence in the SNc and VTA with chronic nicotine (0.4 mg/kg/h; n = 4 mice). *, P < 0.05.

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