Figure 7.

Free dynamics of the toy model for stable (green) and unstable (red) values of the JSR refilling rate. (A) “Number” of open RyRs as a function of time; (B) [Ca2+]JSR ; (C) phase–plane parametric plot of nopen versus casr. (D) Phase–plane plot of number of open RyRs and [Ca2+]JSR in the ensemble average of 10,000 stochastic sparks generated by the full model for stable and unstable parameters. Green, stable: τfill = 6.5 ms (Dup = 0.15); red, unstable: τfill = 1 ms (Dup = 1). Compare with C.

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