Figure 5.

Spark extinction times (5-ms bin width) assuming two values of the JSR refilling rate parameter Dup, with the RyR gating rate constants held fixed at ko = 100 mM−1 ms−1 and kom = 0.1. Increasing Dup to the value predicted from modeling the FSR as a diffuse, random network causes some sparks to “smolder” for a prolonged period rather than extinguishing promptly.

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