Figure 6.
Figure 6. Steady-state force properties of cardiac myofibrils isolated from myocardium of adult zebrafish (filled circles) and from murine papillary muscles (open circles) determined at 10°C. (A) Force–pCa relationships from myofibrils pre-stretched by 15% beyond their slack SLs; data are fitted to Eq. 2 (pCa50 and nH are given in Table I). (B) Passive force responses as a result of mechanical stretch at different successive SLs; data are fitted to the worm-like chain model of entropic elasticity. The inset shows the initial slopes as an estimate of the passive stiffness, 22.5 ± 1.6 kPa/µm for zebrafish and 20.5 ± 1.3 kPa/µm for mouse (1 kPa = 1 nN/µm2). All values were normalized to the CSA of the myofibrils.

Steady-state force properties of cardiac myofibrils isolated from myocardium of adult zebrafish (filled circles) and from murine papillary muscles (open circles) determined at 10°C. (A) Force–pCa relationships from myofibrils pre-stretched by 15% beyond their slack SLs; data are fitted to Eq. 2 (pCa50 and nH are given in Table I). (B) Passive force responses as a result of mechanical stretch at different successive SLs; data are fitted to the worm-like chain model of entropic elasticity. The inset shows the initial slopes as an estimate of the passive stiffness, 22.5 ± 1.6 kPa/µm for zebrafish and 20.5 ± 1.3 kPa/µm for mouse (1 kPa = 1 nN/µm2). All values were normalized to the CSA of the myofibrils.

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